SAHTE ECZANE FUNDAMENTALS EXPLAINED

The functionality of SIK1 in tumorigenesis. SIK1 is usually a tumor suppressor gene, which plays a very important regulatory position in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and affects cancer mobile proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 also can en